Kristi Lin-Rahardja

Kristi Lin-Rahardja

5th-year PhD Student

Theory Division Lab Website

About Me

Hi, I’m Kristi! I am currently a fifth-year PhD candidate in Systems Biology and Bioinformatics at Case Western Reserve University, in Dr. Jacob Scott’s lab at the Cleveland Clinic. I’m utilizing both experimental and computational methods to explore the evolution of drug resistance and sensitivity in cancer, and exploiting these findings to predict drug response and personalize chemotherapy. Following the completion of my doctoral degree, I am eager to continue my career in translational research as a computational biologist and bioinformatician.

Download my CV.

Interests
  • Cancer evolution & resistance
  • Predictive biomarker extraction
  • Bioinformatics & data science
Education

  • PhD in Systems Biology & Bioinformatics, 2020 - present

    Case Western Reserve University

  • BAS in Biotechnology, 2020

    University of Kansas

Skills

Bioinformatics
Statistics
Experimental Evolution

Experience

 
 
 
 
 
CWRU / Cleveland Clinic Lerner Research Institute
Ph.D. Candidate
CWRU / Cleveland Clinic Lerner Research Institute
Jan 2021 – Present Cleveland, OH
  • 5th year
  • Biomarker extraction and validation in chemotherapy-resistant cancer
  • Data Science & Bioinformatics
  • In vitro experimental evolution
  • See projects section below for more details
 
 
 
 
 
Trailhead Biosystems
Bioinformatics Intern
Trailhead Biosystems
Jun 2022 – Aug 2022 Cleveland, OH
  • Single-cell RNA seq data mining and processing
  • Web application development for data presentation and exploration
 
 
 
 
 
Case Western Reserve University
Rotation Student
Case Western Reserve University
Aug 2020 – Dec 2020 Cleveland, OH
  • Thomas LaFramboise, Genetics - Mitochondrial transcriptomics in leukemia
  • Jacob Scott, Systems Biology & Bioinformatics - Modeling cancer evolution in silico
  • Andrew Pieper, Neuroscience - Metabolomics of Alzheimer’s disease and traumatic brain injury
 
 
 
 
 
University of Kansas Medical Center
Research Technician
University of Kansas Medical Center
Aug 2019 – Aug 2020 Kansas City, KS
  • Michele Pritchard, Pharmacology, Toxicology, & Therapeutics
  • Role of hyaluronan synthesis inhibition in activation of hepatic stellate cells in alcohol-associated liver disease
 
 
 
 
 
University of Kansas
Biotechnology Senior Capstone
University of Kansas
Aug 2019 – May 2020 Olathe, KS
  • Environmental bioremediation using genetically modified E. coli to break down PET plastics
 
 
 
 
 
University of Kansas Medical Center
Undergraduate Research Fellow
University of Kansas Medical Center
Jun 2019 – Aug 2019 Kansas City, KS
  • Udayan Apte, Pharmacology, Toxicology, & Therapeutics
  • Molecular role of HNF4-alpha in acetaminophen-induced liver toxicity

Projects

EWS Collateral Sensitivity

EWS Collateral Sensitivity

Uncovering gene signatures of Ewings Sarcoma drug sensitivity during the evolution of resistance

Pilot Study
Transcriptomic Chemogram

Transcriptomic Chemogram

Personalizing chemotherapy with gene expression signatures

Evolution-inspired Signature Extraction Paper Chemogram Preprint

Publications

Kristi Lin-Rahardja, Jessica Scarborough, Jacob Scott (2024). Personalizing chemotherapy drug selection using a novel transcriptomic chemogram.

Cite Pre-print

Manasi Kotulkar, Diego Paine-Cabrera, Sarah Abernathy, Dakota R Robarts, Wendena S Parkes, Kristi Lin-Rahardja, September Numata, Margitta Lebofsky, Hartmut Jaeschke, Udayan Apte (2023). Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury.

Cite Paper

Manasi Kotulkar, Dakota R Robarts, Kristi Lin-Rahardja, Tara McQuillan, Jordan Surgnier, Sarah E Tague, Maciej Czerwinksi, Katie L Dennis, Michele T Pritchard (2023). Hyaluronan synthesis inhibition normalizes ethanol-enhanced hepatic stellate cell activation.

Cite Paper

Kristi Lin-Rahardja, Davis Weaver, Jessica Scarborough, Jacob G Scott (2023). Evolution-Informed Strategies for Combating Drug Resistance in Cancer.

Cite Paper

Roberto Vargas, Aaron Petty, Brian Yard, Arda Durmaz, Kristi Lin-Rahardja, Ofer Reizes, Robert Debernardo, Jacob Scott (2022). Leveraging the p53 signaling pathway as a radio-sensitization strategy in endometrial cancer.

Cite Paper

See all publications

Fun Things

Look at my pets!
I have a lot of animal friends in my life, some more… unorthodox than others. Tsuki This is Tsuki, a ragdoll cat that my uncle found hiding under his porch as a kitten.
Last updated on Aug 6, 2024 3 min read
Look at my pets!

Contact me

I’m happy to chat about the work I’ve done throughout my various research experiences! I’m most accessible through email or LinkedIn.