Kristi Lin-Rahardja

Kristi Lin-Rahardja

PhD in Systems Biology & Bioinformatics

Theory Division Lab Website

About Me

Hi, I’m Kristi! I recently completed my PhD in Systems Biology & Bioinformatics at Case Western Reserve University, where my research focused on exploiting cancer evolution for identifying predictive biomarkers of chemotherapy. I did my dissertation with Jacob Scott (MD, DPhil) at the Cleveland Clinic, where I utilized experimental and computational methods to explore the evolution of drug resistance and sensitivity in cancer, then exploiting these findings to predict drug response and personalize chemotherapy. I’m eager to continue contributing to translational research in oncology or other disease areas through bioinformatics, multi-omic analyses, and statistics. Download my CV.

Interests
  • Cancer evolution & drug resistance
  • Predictive biomarker extraction
  • Bioinformatics & data science
Education
  • PhD in Systems Biology & Bioinformatics, 2020 - 2025

    Case Western Reserve University

  • BAS in Biotechnology, 2017 - 2020

    University of Kansas

Skills

Bioinformatics
Statistics
Experimental Evolution

Experience

 
 
 
 
 
Diasome Pharmaceuticals
Senior Research Associate
Diasome Pharmaceuticals
Jan 2025 – Present Cleveland, OH
  • Developing in vitro and in vivo assays for evaluating the efficacy of multiple co-formulated drug products.
  • Developing analytical methods for quantifying different drug formulations using fluorescent and colorimetric assays, and cryo-EM.
  • Analyzing and interpreting experimental data using R statistical software.
  • Preparing research briefs for Diasome senior scientific staff.
 
 
 
 
 
CWRU / Cleveland Clinic Lerner Research Institute
Ph.D., Systems Biology & Bioinformatics
CWRU / Cleveland Clinic Lerner Research Institute
Jan 2021 – Oct 2025 Cleveland, OH
  • 5th year
  • Biomarker extraction and validation in chemotherapy-resistant cancer
  • Data Science & Bioinformatics
  • In vitro experimental evolution
  • See projects section below for more details
 
 
 
 
 
Trailhead Biosystems
Bioinformatics Intern
Trailhead Biosystems
Jun 2022 – Aug 2022 Cleveland, OH
  • Single-cell RNA seq data mining and processing
  • Web application development for data presentation and exploration
 
 
 
 
 
Case Western Reserve University
Rotation Student
Case Western Reserve University
Aug 2020 – Dec 2020 Cleveland, OH
  • Thomas LaFramboise, Genetics - Mitochondrial transcriptomics in leukemia
  • Jacob Scott, Systems Biology & Bioinformatics - Modeling cancer evolution in silico
  • Andrew Pieper, Neuroscience - Metabolomics of Alzheimer’s disease and traumatic brain injury
 
 
 
 
 
University of Kansas Medical Center
Research Technician
University of Kansas Medical Center
Aug 2019 – Aug 2020 Kansas City, KS
  • Michele Pritchard, Pharmacology, Toxicology, & Therapeutics
  • Role of hyaluronan synthesis inhibition in activation of hepatic stellate cells in alcohol-associated liver disease
 
 
 
 
 
University of Kansas
Biotechnology Senior Capstone
University of Kansas
Aug 2019 – May 2020 Olathe, KS
  • Environmental bioremediation using genetically modified E. coli to break down PET plastics
 
 
 
 
 
University of Kansas Medical Center
Undergraduate Research Fellow
University of Kansas Medical Center
Jun 2019 – Aug 2019 Kansas City, KS
  • Udayan Apte, Pharmacology, Toxicology, & Therapeutics
  • Molecular role of HNF4-alpha in acetaminophen-induced liver toxicity

Projects

EWS Collateral Sensitivity

EWS Collateral Sensitivity

Leveraging Experimental Evolution to Extract Predictive Collateral Drug Response Signatures in Ewings Sarcoma

Contact me

I’m happy to chat about the work I’ve done throughout my various research experiences! I’m most accessible through email or LinkedIn.